Briefly about Anticancer Properties of Statins
نویسندگان
چکیده
منابع مشابه
The statins as anticancer agents.
1,072,503 person-year of follow-up, 195,594 patients died: 162,067 from cancer, 14,489 from cardiovascular causes and 19,038 from other causes. Among patients, 40 years and older, 18,721 received statins before cancer diagnosis and 277. 204 had never used statins. All cause mortality among patients with cancer taking statins was reduced by 15%, and only by 10% as risk for death from cardiovascu...
متن کاملThe statins as anticancer agents.
3-Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins, have proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are emerging interests in their use as anticancer agents based on preclinical evidence of their antiproliferative, proapoptotic, anti-invasive, and radiosensitizing properties. Inhibition of 3-hydroxy-3-methylgutary...
متن کاملNeuroprotective properties of statins.
Treatment with statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) reduces the risk of ischemic stroke among patients with increased risk of vascular disease. Recent experimental data point to neuroprotective properties of statins in acute cerebral ischemia. There is a proven link between bioavailability of nitric oxide and the activity of statins and ischemic stroke. Due to th...
متن کاملPharmacological properties of statins
CoA) reductase inhibitors, or statins, are potent inhibitors of cholesterol biosynthesis. Several large clinical trials have demonstrated the benefits of cholesterol lowering with these agents in the primary and secondary prevention of coronary heart disease. The overall clinical benefits observed with statin therapy, however, appear to be greater than what might be expected from changes in lip...
متن کاملAnticancer Properties of Lamellarins
In 1985 the first lamellarins were isolated from a small oceanic sea snail. Today, more than 50 lamellarins have been inventoried and numerous derivatives synthesized and tested as antiviral or anticancer agents. The lead compound in the family is lamellarin D, characterized as a potent inhibitor of both nuclear and mitochondrial topoisomerase I but also capable of directly interfering with mit...
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ژورنال
عنوان ژورنال: Biomedical Journal of Scientific & Technical Research
سال: 2019
ISSN: 2574-1241
DOI: 10.26717/bjstr.2019.17.002975